Farklı çapraz bağlayıcılar ile hazırlanmış poliakrilamid hidrojellerinin değerlendirilmesi

Sema Ekici, Meziyet Çetik Erkol

Öz


Çapraz bağlı poliakrilamid (PAAm) hidrojelleri; fiziksel özellikleri üzerine çapraz bağlayıcı türü etkisinin incelenmesi amacıyla sentezlenmiştir. Bu amaçla; N,N’-metilenbisakrilamid (MBA), trietilen glikol dimetakrilat (TEGDMA), glutaraldehit (GLU), divinilsülfon (DVS), N,N’-Diallil L-ltartardiamit (DATD) ve epiklorhidrin (ECH;) çapraz bağlayıcılar olarak seçilmiş ve bu hidrojeller sırasıyla PAAm-MBA, PAAm-TEGDMA, PAAm-GLU, PAAm-DVS, PAAm-DATD, PAAm-ECH olarak isimlendirilmiştir. Tüm çapraz bağlayıcılar için nçapraz bağlayıcı/nmonomer oranı=%2.5 olarak sabitlenmiştir. Amonyumpersülfat (APS) ve N,N,N’,N’-tetrametiletilendiamin (TEMED); redoks başlatıcısı-hızlandırıcısı olarak seçilmiş ve PAAm hidrojelleri; çapraz bağlayıcıların bulunduğu ortamda monomerlerin radikalik polimerleşmesi ile hazırlanmıştır. PAAm hidrojellerinin şişme ve difüzyon parametrelerinin hesaplanabilmesi amacıyla kinetik şişme çalışmaları; deiyonize suda (DS) ve 25 oC’de gerçekleştirilmiştir. Deneysel şişme verileri; şişme prosesinin 2o’den kinetiğe uyduğunu göstermiştir. PAAm hidrojellerinin şişme dereceleri; PAAm-ECH>PAAm-DVS>PAAm-MBA=PAAm-DATD>PAAm-GLU>PAAm-TEGDMA olarak bulunmuştur. PAAm hidrojelleri; su moleküllerinin hidrojellere difüzyon türünün Fick tipi olmayan difüzyon türü olduğunu gösteren ve değeri 0.57 ve 0.80 aralığında değişen sayılara (n) sahiptir. PAAm hidrojellerinin çapraz bağlar arası ortalama mol kütlesi (), çapraz bağ yoğunluğu (q) ve gözeneklilik (P) gibi ağ yapı parametreleri hesaplanmıştır. Denge şişme çalışmaları; protein (sığır serumu albumini, BSA), bakteriyel polisakkarit (dekstran, DEX), vitamin (nikotinamid, NAD) ve ilaç etken maddesi (8-hidroksi 7-iyodokinolin-5-sülfonik asit, HKSA) çözeltilerinde de yapılmıştır. Şişme ve ağ yapı parametreleri, PAAm hidrojelleri; yapısı protein, karbohidrat, vitamin ve ilaç etken moleküllerine benzeyen moleküller ile etkileştrildiğinde şişme ve adsorpsiyon özelliklerinin tahmin edilmesinde yol gösterici olacaktır. 


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